diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java
index b538ef63a..26e7b4fbb 100755
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java
@@ -728,8 +728,12 @@ public class DoctorStationAdviceAppServiceImpl implements IDoctorStationAdviceAp
 
             /**
              * 处理耗材请求
+             * 🔧 BugFix #443: 签发时跳过 handDevice，避免重复创建 DeviceDispense 并覆盖关键字段（如 performLocation）
+             * 签发时只需更新状态（下方 sign-advice 批量更新逻辑已处理）
              */
-            this.handDevice(deviceList, curDate, adviceOpType);
+            if (AdviceOpType.SAVE_ADVICE.getCode().equals(adviceOpType)) {
+                this.handDevice(deviceList, curDate, adviceOpType);
+            }
 
             // 签发时,把草稿状态的账单更新为待收费
             if (AdviceOpType.SIGN_ADVICE.getCode().equals(adviceOpType) && !adviceSaveList.isEmpty()) {