diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/RequestFormManageAppServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/RequestFormManageAppServiceImpl.java
index 4dd649fad..ad87b75c4 100755
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/RequestFormManageAppServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/RequestFormManageAppServiceImpl.java
@@ -76,6 +76,10 @@ public class RequestFormManageAppServiceImpl implements IRequestFormManageAppSer
     @Override
     @Transactional(rollbackFor = Exception.class)
     public R<?> saveRequestForm(RequestFormSaveDto requestFormSaveDto, String typeCode) {
+        // 申请单ID（前端空字符串可能反序列化为0L，需同时判0）
+        Long requestFormId = requestFormSaveDto.getRequestFormId();
+        boolean isEdit = requestFormId != null && requestFormId != 0L;
+
         // 诊疗执行科室配置校验（必须在任何数据库操作之前）
         List<ActivityOrganizationConfigDto> activityOrganizationConfig =
             requestFormManageAppMapper.getActivityOrganizationConfig(typeCode);
@@ -83,12 +87,23 @@ public class RequestFormManageAppServiceImpl implements IRequestFormManageAppSer
             throw new ServiceException("请先配置当前时间段的执行科室");
         }
 
+        // 逐个校验activityList中的项目是否都配置了执行科室，避免部分通过后在循环中抛异常导致事务复杂化
+        List<ActivitySaveDto> activityList = requestFormSaveDto.getActivityList();
+        if (activityList != null && !activityList.isEmpty()) {
+            for (ActivitySaveDto activitySaveDto : activityList) {
+                Long positionId = activityOrganizationConfig.stream()
+                    .filter(dto -> activitySaveDto.getAdviceDefinitionId().equals(dto.getActivityDefinitionId()))
+                    .map(ActivityOrganizationConfigDto::getOrganizationId).findFirst().orElse(null);
+                if (positionId == null) {
+                    throw new ServiceException(activitySaveDto.getAdviceDefinitionName() + "未配置当前时间段的执行科室");
+                }
+            }
+        }
+
         // 诊疗处方号
         String prescriptionNo;
-        // 申请单ID
-        Long requestFormId = requestFormSaveDto.getRequestFormId();
         // 编辑场景
-        if (requestFormId != null) {
+        if (isEdit) {
             RequestForm requestFormInfo = iRequestFormService.getById(requestFormId);
             prescriptionNo = requestFormInfo.getPrescriptionNo();
             // 该申请单存在的待发送医嘱个数
@@ -132,7 +147,7 @@ public class RequestFormManageAppServiceImpl implements IRequestFormManageAppSer
         iRequestFormService.saveOrUpdate(requestForm);
 
         // 编辑场景时,先删除掉原有诊疗项目及账单再新增
-        if (requestFormId != null) {
+        if (isEdit) {
             List<Long> serviceRequestIds = iServiceRequestService
                 .list(new LambdaQueryWrapper<ServiceRequest>().eq(ServiceRequest::getPrescriptionNo, prescriptionNo))
                 .stream().map(ServiceRequest::getId).collect(Collectors.toList());
@@ -146,8 +161,6 @@ public class RequestFormManageAppServiceImpl implements IRequestFormManageAppSer
 
         ServiceRequest serviceRequest;
         ChargeItem chargeItem;
-        // 诊疗集合
-        List<ActivitySaveDto> activityList = requestFormSaveDto.getActivityList();
         log.info("保存申请单，typeCode={}, activityListSize={}, encounterId={}", typeCode, activityList != null ? activityList.size() : 0, encounterId);
 
         for (ActivitySaveDto activitySaveDto : activityList) {