diff --git a/healthlink-his-ui/src/views/inpatientDoctor/home/components/order/index.vue b/healthlink-his-ui/src/views/inpatientDoctor/home/components/order/index.vue
index 2dd1e4151..6e4ef6eb5 100755
--- a/healthlink-his-ui/src/views/inpatientDoctor/home/components/order/index.vue
+++ b/healthlink-his-ui/src/views/inpatientDoctor/home/components/order/index.vue
@@ -6,7 +6,7 @@
           新增
         </el-button>
         <el-button type="primary" @click="handleSaveBatch()" :disabled="false"> 保存 </el-button>
-        <el-button type="primary" @click="handleSave()" :disabled="isSaveDisabled"> 签发 </el-button>
+        <el-button type="primary" :loading="loading || isSaving" :disabled="isSaveDisabled || loading || isSaving" @click="handleSave()"> 签发 </el-button>
         <el-button type="warning" plain @click="handleSingOut()" :disabled="false">
           撤回
         </el-button>
@@ -1605,6 +1605,8 @@ function handleSave() {
         if (res.code === 200) {
           proxy.$modal.msgSuccess('签发成功');
           isSaving.value = false;
+          // 清除勾选状态
+          prescriptionRef.value?.clearCheckboxRow();
           getListInfo(false);
           bindMethod.value = {};
           nextId.value == 1;