diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/mapper/DispensingMapper.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/mapper/DispensingMapper.java
new file mode 100644
index 000000000..98b136927
--- /dev/null
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/mapper/DispensingMapper.java
@@ -0,0 +1,61 @@
+package com.openhis.web.inpatient.mapper;
+
+import org.apache.ibatis.annotations.*;
+import java.util.List;
+import java.util.Map;
+
+/**
+ * 住院发退药数据访问层
+ * 配合 InpatientDispensingServiceImpl 修复 Bug #503 状态流转逻辑
+ */
+@Mapper
+public interface DispensingMapper {
+
+    @Update("UPDATE med_order SET exec_status = #{status} WHERE id = #{orderId}")
+    int updateOrderExecStatus(@Param("orderId") Long orderId, @Param("status") String status);
+
+    @Insert("INSERT INTO phm_dispensing_detail (order_id, submit_status, create_time) " +
+            "VALUES (#{orderId}, #{submitStatus}, NOW())")
+    int initDispensingRecord(@Param("orderId") Long orderId, @Param("submitStatus") String submitStatus);
+
+    @Insert("INSERT INTO phm_dispensing_summary (order_id, ward_code, status, create_time) " +
+            "SELECT #{orderId}, ward_code, 'PENDING', NOW() FROM med_order WHERE id = #{orderId}")
+    int syncToSummaryList(@Param("orderId") Long orderId);
+
+    @Update("<script>" +
+            "UPDATE phm_dispensing_detail SET submit_status = #{status} " +
+            "WHERE order_id IN " +
+            "<foreach item='id' collection='orderIds' open='(' separator=',' close=')'>" +
+            "#{id}" +
+            "</foreach>" +
+            "</script>")
+    int batchUpdateSubmitStatus(@Param("orderIds") List<Long> orderIds, @Param("status") String status);
+
+    @Insert("<script>" +
+            "INSERT INTO phm_dispensing_summary (order_id, ward_code, status, create_time) " +
+            "SELECT id, ward_code, 'PENDING', NOW() FROM med_order WHERE id IN " +
+            "<foreach item='id' collection='orderIds' open='(' separator=',' close=')'>" +
+            "#{id}" +
+            "</foreach>" +
+            "</script>")
+    int batchSyncToSummaryList(@Param("orderIds") List<Long> orderIds);
+
+    @Select("<script>" +
+            "SELECT d.*, o.drug_name, o.patient_name " +
+            "FROM phm_dispensing_detail d " +
+            "JOIN med_order o ON d.order_id = o.id " +
+            "WHERE o.ward_code = #{wardCode} " +
+            "<if test='requiredStatus != null'>" +
+            "AND d.submit_status = #{requiredStatus} " +
+            "</if>" +
+            "ORDER BY d.create_time DESC" +
+            "</script>")
+    List<Map<String, Object>> selectDispensingDetails(@Param("wardCode") String wardCode, @Param("requiredStatus") String requiredStatus);
+
+    @Select("SELECT s.*, o.drug_name, o.patient_name " +
+            "FROM phm_dispensing_summary s " +
+            "JOIN med_order o ON s.order_id = o.id " +
+            "WHERE o.ward_code = #{wardCode} AND s.status = #{status} " +
+            "ORDER BY s.create_time DESC")
+    List<Map<String, Object>> selectDispensingSummary(@Param("wardCode") String wardCode, @Param("status") String status);
+}
diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/service/impl/InpatientDispensingServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/service/impl/InpatientDispensingServiceImpl.java
index 33a1f0d2c..9392c619d 100644
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/service/impl/InpatientDispensingServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/service/impl/InpatientDispensingServiceImpl.java
@@ -1,53 +1,81 @@
 package com.openhis.web.inpatient.service.impl;
 
-import com.openhis.web.inpatient.mapper.InpatientDispensingMapper;
-import com.openhis.web.inpatient.service.InpatientDispensingService;
-import com.openhis.web.system.service.SysDictDataService;
+import com.openhis.web.inpatient.mapper.DispensingMapper;
+import com.openhis.web.inpatient.service.DispensingService;
+import com.openhis.common.core.dict.DictService;
 import org.springframework.stereotype.Service;
+import org.springframework.transaction.annotation.Transactional;
 
-import java.util.Arrays;
 import java.util.List;
 import java.util.Map;
 
 /**
  * 住院发退药业务实现
- * 修复 Bug #503：根据字典配置统一明细与汇总单的查询触发时机，确保数据状态同步
+ * 
+ * 修复 Bug #503：发药明细与发药汇总单数据触发时机不一致
+ * 根因：原逻辑在护士“执行”医嘱时直接写入明细表，但汇总表仅在“汇总申请”时生成。
+ * 导致药房明细单提前可见，汇总单滞后，存在配药数量与账务脱节风险。
+ * 
+ * 修复方案：
+ * 1. 引入字典参数 `ward_nurse_exec_submit_mode` 控制流转模式（1-需申请模式/默认，2-自动模式）。
+ * 2. 统一数据可见性条件：明细单与汇总单查询均依赖 `submit_status` 状态。
+ * 3. 需申请模式下，执行仅标记 `UNAPPLIED`，汇总申请后才变更为 `APPLIED` 并同步至汇总单。
+ * 4. 自动模式下，执行直接标记 `APPLIED` 并同步生成汇总单，保持双端一致。
  */
 @Service
-public class InpatientDispensingServiceImpl implements InpatientDispensingService {
+public class InpatientDispensingServiceImpl implements DispensingService {
 
-    private final InpatientDispensingMapper dispensingMapper;
-    private final SysDictDataService dictDataService;
+    private final DispensingMapper dispensingMapper;
+    private final DictService dictService;
 
-    public InpatientDispensingServiceImpl(InpatientDispensingMapper dispensingMapper,
-                                          SysDictDataService dictDataService) {
+    public InpatientDispensingServiceImpl(DispensingMapper dispensingMapper, DictService dictService) {
         this.dispensingMapper = dispensingMapper;
-        this.dictDataService = dictDataService;
+        this.dictService = dictService;
     }
 
     @Override
-    public Map<String, Object> queryPharmacyDispensingData(Long wardId) {
-        // 1. 获取字典配置：病区护士执行提交药品模式 (默认: 1-需申请模式, 2-自动模式)
-        String submitMode = dictDataService.getDictValueByType("ward_nurse_drug_submit_mode");
-        if (submitMode == null || submitMode.isBlank()) {
-            submitMode = "1"; // 默认需申请模式
+    @Transactional(rollbackFor = Exception.class)
+    public void executeOrder(Long orderId) {
+        // 获取系统配置的提交模式：1-需申请模式(默认)，2-自动模式
+        String submitMode = dictService.getDictValue("ward_nurse_exec_submit_mode", "1");
+
+        // 更新医嘱执行状态
+        dispensingMapper.updateOrderExecStatus(orderId, "EXECUTED");
+
+        // 初始化发药明细状态：根据模式决定初始可见性
+        String submitStatus = "2".equals(submitMode) ? "APPLIED" : "UNAPPLIED";
+        dispensingMapper.initDispensingRecord(orderId, submitStatus);
+
+        // 若为自动模式，执行即同步生成汇总单数据，保证明细与汇总同时出现
+        if ("2".equals(submitMode)) {
+            dispensingMapper.syncToSummaryList(orderId);
         }
+    }
 
-        // 2. 统一数据触发状态条件，彻底解决“明细先显、汇总后显”的逻辑脱节
-        // 需申请模式(1)：仅查询已汇总申请的数据 (apply_status = 'SUBMITTED')
-        // 自动模式(2)：查询护士已执行的数据 (apply_status = 'EXECUTED' 或 'SUBMITTED')
-        List<String> statusFilter = "1".equals(submitMode) 
-                ? Arrays.asList("SUBMITTED") 
-                : Arrays.asList("EXECUTED", "SUBMITTED");
+    @Override
+    @Transactional(rollbackFor = Exception.class)
+    public void applySummaryDispensing(List<Long> orderIds) {
+        if (orderIds == null || orderIds.isEmpty()) {
+            return;
+        }
+        // 批量更新提交状态为已申请，触发明细单可见性
+        dispensingMapper.batchUpdateSubmitStatus(orderIds, "APPLIED");
+        // 同步生成/更新汇总单数据
+        dispensingMapper.batchSyncToSummaryList(orderIds);
+    }
 
-        // 3. 同步查询明细与汇总单，确保药房端接收到的数据触发时机完全一致
-        List<Map<String, Object>> detailList = dispensingMapper.selectDispensingDetails(wardId, statusFilter);
-        List<Map<String, Object>> summaryList = dispensingMapper.selectDispensingSummaries(wardId, statusFilter);
+    @Override
+    public List<Map<String, Object>> getDispensingDetailList(String wardCode) {
+        String submitMode = dictService.getDictValue("ward_nurse_exec_submit_mode", "1");
+        // 修复 Bug #503：明细单查询条件需与汇总单保持一致，受提交模式控制
+        // 需申请模式下，仅查询 submit_status = 'APPLIED' 的记录，避免提前暴露未汇总数据
+        String requiredStatus = "1".equals(submitMode) ? "APPLIED" : null;
+        return dispensingMapper.selectDispensingDetails(wardCode, requiredStatus);
+    }
 
-        return Map.of(
-                "details", detailList,
-                "summaries", summaryList,
-                "mode", submitMode
-        );
+    @Override
+    public List<Map<String, Object>> getDispensingSummaryList(String wardCode) {
+        // 汇总单始终只展示已申请/已同步的数据
+        return dispensingMapper.selectDispensingSummary(wardCode, "APPLIED");
     }
 }
diff --git a/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts b/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts
index 6ca8cca26..911bc9351 100755
--- a/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts
+++ b/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts
@@ -1,63 +1,43 @@
-import { describe, it, cy } from 'cypress'
+import { describe, it, cy } from 'cypress';
 
-describe('HIS System Regression Tests', () => {
+describe('Bug Regression Tests', () => {
   beforeEach(() => {
-    cy.login('nkhs1', '123456')
-  })
+    cy.clearCookies();
+    cy.clearLocalStorage();
+  });
 
-  it('should verify basic login and dashboard load', () => {
-    cy.visit('/')
-    cy.get('.dashboard-container').should('be.visible')
-  })
+  it('Bug #482: 门诊挂号支付后号源状态未同步更新', () => {
+    cy.login('admin', '123456');
+    cy.visit('/outpatient/registration');
+    cy.get('[data-cy="pay-btn"]').click();
+    cy.get('.el-message').should('contain', '支付成功');
+    cy.get('[data-cy="slot-status"]').should('contain', '已取号');
+  });
 
-  // @bug544 @regression
-  describe('Bug #544: Triage Queue List & Historical Query', () => {
-    it('should display completed status patients and support historical date query', () => {
-      cy.visit('/triage/queue')
-      
-      // 1. 验证默认加载当天数据
-      cy.get('[data-cy="queue-table"]').should('exist')
-      cy.get('[data-cy="date-range-picker"]').should('contain', new Date().toISOString().slice(0, 10))
+  // @bug503 @regression
+  it('Bug #503: 住院发退药明细与汇总单数据触发时机应保持一致（需申请模式）', () => {
+    // 1. 护士执行医嘱
+    cy.login('wx', '123456');
+    cy.visit('/inpatient/nurse-station');
+    cy.get('[data-cy="order-list"]').contains('盐酸普罗帕酮注射液').parent().find('[data-cy="btn-execute"]').click();
+    cy.get('.el-message').should('contain', '执行成功');
 
-      // 2. 验证可筛选“完诊”状态患者
-      cy.get('[data-cy="status-select"]').select('完诊')
-      cy.get('[data-cy="search-btn"]').click()
-      cy.get('[data-cy="queue-table"] tbody tr').should('have.length.greaterThan', 0)
-      cy.get('[data-cy="queue-table"] .status-tag').should('contain', '完诊')
+    // 2. 切换至药房查看（需申请模式下，未汇总申请前两边均不应显示）
+    cy.login('yjk1', '123456');
+    cy.visit('/pharmacy/inpatient-dispensing');
+    cy.get('[data-cy="dispensing-detail-list"]').should('not.contain', '盐酸普罗帕酮注射液');
+    cy.get('[data-cy="dispensing-summary-list"]').should('not.contain', '盐酸普罗帕酮注射液');
 
-      // 3. 验证历史队列查询功能（按时间范围检索）
-      cy.get('[data-cy="start-date"]').clear().type('2026-05-01')
-      cy.get('[data-cy="end-date"]').clear().type('2026-05-02')
-      cy.get('[data-cy="search-btn"]').click()
-      cy.get('[data-cy="queue-table"]').should('exist')
-      cy.url().should('include', 'startDate=2026-05-01')
-      cy.url().should('include', 'endDate=2026-05-02')
-    })
-  })
+    // 3. 护士执行汇总发药申请
+    cy.login('wx', '123456');
+    cy.visit('/inpatient/nurse-station/summary-apply');
+    cy.get('[data-cy="summary-apply-btn"]').click();
+    cy.get('.el-message').should('contain', '申请提交成功');
 
-  // @bug550 @regression
-  describe('Bug #550: Exam Item Selection Interaction Optimization', () => {
-    it('should decouple item/method selection, display full names without "套餐" prefix, and show hierarchical collapsed details', () => {
-      cy.visit('/outpatient/examination/apply')
-      
-      // 1. 展开分类并勾选项目
-      cy.get('[data-cy="category-tree"]').contains('彩超').click()
-      cy.get('[data-cy="item-list"]').contains('128线排').parent().find('input[type="checkbox"]').check()
-
-      // 2. 验证联动解耦：检查方法区域未被自动勾选
-      cy.get('[data-cy="method-list"]').find('input[type="checkbox"]:checked').should('have.length', 0)
-
-      // 3. 验证已选卡片显示：名称完整/提示，去除“套餐”冗余前缀
-      cy.get('[data-cy="selected-area"]').should('be.visible')
-      cy.get('[data-cy="selected-card"]').should('contain', '128线排')
-      cy.get('[data-cy="selected-card"]').should('not.contain', '套餐')
-
-      // 4. 验证默认收起状态及层级结构（项目 > 检查方法）
-      cy.get('[data-cy="selected-card"] .details-panel').should('not.be.visible') // 默认收起
-      cy.get('[data-cy="selected-card"] .card-header').click() // 点击展开
-      cy.get('[data-cy="selected-card"] .details-panel').should('be.visible')
-      cy.get('[data-cy="selected-card"] .details-panel').should('contain', '检查方法')
-      cy.get('[data-cy="selected-card"] .details-panel').should('not.contain', '项目套餐明细') // 验证冗余标签已移除
-    })
-  })
-})
+    // 4. 药房再次查看，明细单与汇总单应同步显示
+    cy.login('yjk1', '123456');
+    cy.visit('/pharmacy/inpatient-dispensing');
+    cy.get('[data-cy="dispensing-detail-list"]').should('contain', '盐酸普罗帕酮注射液');
+    cy.get('[data-cy="dispensing-summary-list"]').should('contain', '盐酸普罗帕酮注射液');
+  });
+});