diff --git a/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue b/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue
index ef47a8e7..58495e87 100755
--- a/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue
+++ b/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue
@@ -631,6 +631,12 @@ function getListInfo(addNewRow) {
         handleAddPrescription();
       }
     });
+  }).catch((err) => {
+    console.error('处方列表加载失败:', err);
+    // 🔧 Bug #405 修复：列表加载失败时，确保所有行被锁定（isEdit=false）
+    // 防止行永久处于可编辑状态
+    prescriptionList.value.forEach(item => { item.isEdit = false; });
+    loadingInstance.close();
   });
   getContract({ encounterId: patientInfo.value.encounterId }).then((res) => {
     contractList.value = res.data;
@@ -1443,6 +1449,12 @@ function handleSaveBatch() {
     })
     .catch((error) => {
       isSaving.value = false;
+      // 🔧 Bug #405 修复：保存失败时也锁定行，防止行永久处于可编辑状态
+      filterPrescriptionList.value.forEach(item => {
+        if (item.statusEnum == 1 && !item.requestId) {
+          item.isEdit = false;
+        }
+      });
       proxy.$modal.msgError(error?.msg || '保存失败，请重试');
     });
 }