diff --git a/healthlink-his-ui/src/views/doctorstation/components/tcm/tcmAdvice.vue b/healthlink-his-ui/src/views/doctorstation/components/tcm/tcmAdvice.vue
index 8cd916b4b..45a8480f6 100755
--- a/healthlink-his-ui/src/views/doctorstation/components/tcm/tcmAdvice.vue
+++ b/healthlink-his-ui/src/views/doctorstation/components/tcm/tcmAdvice.vue
@@ -193,13 +193,13 @@
           />
         </div>
         <vxe-table
-          ref="prescriptionRef"
+          :ref="(el) => { if (el) tableRefs[pIndex] = el }"
           v-loading="loading"
           :data="prescription.prescriptionList"
           :row-config="{ keyField: 'uniqueKey', expandRowKeys: prescription.expandOrder }"
           border
           @cell-click="clickRow"
-          @cell-dblclick="(row) => clickRowDb(row, pIndex)"
+          @cell-dblclick="({ row }) => clickRowDb(row, pIndex)"
         >
           <vxe-column
             type="expand"
@@ -217,8 +217,8 @@
                   style="padding: 16px; background: #f8f9fa; border-radius: 8px"
                 >
                   <template v-if="scope.row.adviceType == 1">
-                    <div style="display: flex; align-items: center; margin-bottom: 16px; gap: 8px">
-                      <span class="medicine-title">
+                    <div style="display: flex; align-items: center; gap: 10px; flex-wrap: nowrap">
+                      <span class="medicine-title" style="flex-shrink: 0">
                         {{
                           scope.row.adviceName +
                             ' ' +
@@ -230,119 +230,45 @@
                             ']'
                         }}
                       </span>
-                      <el-form-item
-                        prop="lotNumber"
-                        label="药房："
-                      >
-                        <el-select
-                          v-model="scope.row.inventoryId"
-                          style="width: 380px; margin-right: 20px"
-                          placeholder="药房"
-                        >
+                      <el-form-item prop="lotNumber" label="药房：" style="margin-bottom: 0; flex-shrink: 0">
+                        <el-select v-model="scope.row.inventoryId" style="width: 280px" placeholder="药房">
                           <el-option
                             v-for="item in scope.row.stockList"
                             :key="item.inventoryId"
                             :value="item.inventoryId"
-                            :label="
-                              item.locationName +
-                                '  ' +
-                                '批次号: ' +
-                                item.lotNumber +
-                                '  ' +
-                                '  库存：' +
-                                item.quantity / scope.row.partPercent +
-                                item.unitCode_dictText +
-                                '  单价：' +
-                                item.price.toFixed(2) +
-                                '/' +
-                                item.unitCode_dictText
-                            "
+                            :label="item.locationName + '  库存：' + item.quantity / scope.row.partPercent + item.unitCode_dictText + '  单价：' + item.price.toFixed(2) + '/' + item.unitCode_dictText"
                             @click="handleNumberClick(item, scope.rowIndex, pIndex)"
                           />
                         </el-select>
                       </el-form-item>
-                      <div class="form-group">
-                        <!-- 单次剂量 -->
-                        <el-form-item
-                          label="数量："
-                          prop="minUnitQuantity"
-                          class="required-field"
-                          data-prop="minUnitQuantity"
-                        >
-                          <el-input-number
-                            :ref="(el) => (inputRefs.minUnitQuantity = el)"
-                            v-model="scope.row.minUnitQuantity"
-                            :min="0"
-                            controls-position="right"
-                            :controls="false"
-                            style="width: 70px; margin-right: 20px"
-                            @input="
-                              () => {
-                                nextTick(() => {
-                                  scope.row.totalPrice =
-                                    scope.row.minUnitQuantity * scope.row.unitPrice;
-                                });
-                              }
-                            "
-                            @keyup.enter.prevent="
-                              handleEnter('minUnitQuantity', scope.row, scope.rowIndex, pIndex)
-                            "
+                      <el-form-item label="数量：" prop="minUnitQuantity" class="required-field" data-prop="minUnitQuantity" style="margin-bottom: 0; flex-shrink: 0">
+                        <el-input-number
+                          :ref="(el) => (inputRefs.minUnitQuantity = el)"
+                          v-model="scope.row.minUnitQuantity"
+                          :min="0" controls-position="right" :controls="false" style="width: 75px"
+                          @input="() => { nextTick(() => { scope.row.totalPrice = scope.row.minUnitQuantity * scope.row.unitPrice; }); }"
+                          @keyup.enter.prevent="handleEnter('minUnitQuantity', scope.row, scope.rowIndex, pIndex)"
+                        />
+                      </el-form-item>
+                      <el-select v-model="scope.row.minUnitCode" style="width: 75px; flex-shrink: 0" placeholder=" ">
+                        <template v-for="item in scope.row.unitCodeList" :key="item.value">
+                          <el-option
+                            v-if="scope.row.unitCodeList.length == 3 ? item.type == unitMap['minUnit'] : item.type == unitMap['unit']"
+                            :value="item.value" :label="item.label"
                           />
-                        </el-form-item>
-                        <!-- 剂量单位 -->
-                        <el-select
-                          v-model="scope.row.minUnitCode"
-                          style="width: 80px; margin-right: 20px"
-                          placeholder=" "
-                        >
-                          <template
-                            v-for="item in scope.row.unitCodeList"
-                            :key="item.value"
-                          >
-                            <el-option
-                              v-if="
-                                scope.row.unitCodeList.length == 3
-                                  ? item.type == unitMap['minUnit']
-                                  : item.type == unitMap['unit']
-                              "
-                              :value="item.value"
-                              :label="item.label"
-                            />
+                        </template>
+                      </el-select>
+                      <el-form-item label="特殊煎法：" prop="dosageInstruction" class="required-field" data-prop="dosageInstruction" style="margin-bottom: 0; flex-shrink: 0">
+                        <el-select v-model="scope.row.dosageInstruction" style="width: 95px" placeholder=" ">
+                          <template v-for="item in dosage_instruction" :key="item.value">
+                            <el-option :value="item.value" :label="item.label" />
                           </template>
                         </el-select>
-                        <!-- 单次剂量 -->
-                        <el-form-item
-                          label="特殊煎法："
-                          prop="dosageInstruction"
-                          class="required-field"
-                          data-prop="dosageInstruction"
-                        >
-                          <el-select
-                            v-model="scope.row.dosageInstruction"
-                            style="width: 90px; margin-right: 20px"
-                            placeholder=" "
-                          >
-                            <template
-                              v-for="item in dosage_instruction"
-                              :key="item.value"
-                            >
-                              <el-option
-                                :value="item.value"
-                                :label="item.label"
-                              />
-                            </template>
-                          </el-select>
-                        </el-form-item>
-                      </div>
-                      <span class="total-amount">
-                        总金额：{{
-                          scope.row.totalPrice ? scope.row.totalPrice + ' 元' : '0.00 元'
-                        }}
+                      </el-form-item>
+                      <span class="total-amount" style="flex-shrink: 0; white-space: nowrap">
+                        总金额：{{ scope.row.totalPrice ? scope.row.totalPrice + ' 元' : '0.00 元' }}
                       </span>
-                      <el-button
-                        type="primary"
-                        @click="handleSaveSign(scope.row, scope.rowIndex, pIndex)"
-                      >
+                      <el-button type="primary" style="flex-shrink: 0" @click="handleSaveSign(scope.row, scope.rowIndex, pIndex)">
                         确定
                       </el-button>
                     </div>
@@ -394,7 +320,7 @@
                   :width="1200"
                 >
                   <tcmMedicineList
-                    ref="adviceTableRef"
+                    :ref="(el) => { if (el) activeAdviceTable = el }"
                     :popover-visible="scope.row.showPopover"
                     :advice-query-params="adviceQueryParams"
                     :patient-info="props.patientInfo"
@@ -416,7 +342,7 @@
                           if (['ArrowUp', 'ArrowDown', 'Enter'].includes(e.key)) {
                             e.preventDefault();
                             // 传递事件到弹窗容器
-                            adviceTableRef.handleKeyDown(e);
+                            activeAdviceTable?.handleKeyDown(e);
                           }
                         }
                       "
@@ -602,7 +528,7 @@ const tcmPrescriptionList = ref([
   },
 ]);
 const unitCodeList = ref([]);
-const adviceTableRef = ref([]);
+const activeAdviceTable = ref(null);
 const organization = ref([]);
 const loading = ref(false);
 const rowRules = ref({
@@ -625,7 +551,7 @@ const props = defineProps({
     type: String,
   },
 });
-const prescriptionRef = ref();
+const tableRefs = ref({});
 const stockList = ref([]);
 const contractList = ref([]);
 const tcmDiagnosisList = ref([]);
@@ -842,7 +768,7 @@ function handleAddMedicine(pIndex) {
 /**
  * 点击行赋值
  */
-function clickRow(row) {
+function clickRow({ row }) {
   emit('selectDiagnosis', row);
 }
 
@@ -856,7 +782,7 @@ function clickRowDb(row, pIndex) {
     const index = prescription.prescriptionList.findIndex(
       (item) => item.uniqueKey === row.uniqueKey
     );
-    prescription.prescriptionList[index] = row;
+    prescription.prescriptionList.splice(index, 1, row);
     prescription.expandOrder = [row.uniqueKey];
   }
 }
@@ -873,8 +799,14 @@ function handleFocus(row, index, pIndex) {
   row.showPopover = true;
 }
 
+let blurTimer = null;
+
 function handleBlur(row) {
-  row.showPopover = false;
+  if (blurTimer) clearTimeout(blurTimer);
+  blurTimer = setTimeout(() => {
+    row.showPopover = false;
+    blurTimer = null;
+  }, 200);
 }
 
 function handleChange(value) {
@@ -995,96 +927,59 @@ function getPrescriptionMedicineCount(prescriptionIndex) {
  * 选择药品回调
  */
 function selectAdviceBase(key, row, pIndex) {
-  // ... 保持原有逻辑，但使用对应处方的数据 ...
   const prescription = tcmPrescriptionList.value[pIndex];
   getOrgList();
   unitCodeList.value = [];
-  unitCodeList.value.push({ value: row.unitCode, label: row.unitCode_dictText, type: 'unit' });
+  unitCodeList.value.push({ value: row.unitCode, label: row.unitCode_dictText, type: "unit" });
   if (row.doseUnitCode != row.minUnitCode) {
-    unitCodeList.value.push({
-      value: row.doseUnitCode,
-      label: row.doseUnitCode_dictText,
-      type: 'dose',
-    });
+    unitCodeList.value.push({ value: row.doseUnitCode, label: row.doseUnitCode_dictText, type: "dose" });
   }
-  if (
-    (row.partAttributeEnum == 1 || row.partAttributeEnum == 3) &&
-    row.minUnitCode != row.unitCode
-  ) {
-    unitCodeList.value.push({
-      value: row.minUnitCode,
-      label: row.minUnitCode_dictText,
-      type: 'minUnit',
-    });
+  if ((row.partAttributeEnum == 1 || row.partAttributeEnum == 3) && row.minUnitCode != row.unitCode) {
+    unitCodeList.value.push({ value: row.minUnitCode, label: row.minUnitCode_dictText, type: "minUnit" });
   }
   if (row.adviceType == 2 && row.minUnitCode != row.unitCode) {
-    unitCodeList.value.push({
-      value: row.minUnitCode,
-      label: row.minUnitCode_dictText,
-      type: 'minUnit',
-    });
+    unitCodeList.value.push({ value: row.minUnitCode, label: row.minUnitCode_dictText, type: "minUnit" });
   }
+  // vxe-table v4: keep row ref, mutate in-place (ref prescriptionlist.vue setValue)
+  const existingRow = prescription.prescriptionList[rowIndex.value];
+  if (!existingRow) return;
+  const pk = existingRow.uniqueKey, pe = existingRow.isEdit, pg = existingRow.groupId;
+  Object.keys(existingRow).forEach(k => { delete existingRow[k]; });
   const rowData = JSON.parse(JSON.stringify(row));
-  prescription.prescriptionList[rowIndex.value] = {
-    ...prescription.prescriptionList[rowIndex.value], // 保留原有属性（如 uniqueKey, groupId）
-    ...rowData, // 覆盖药品信息
-    statusEnum: 1, // 【关键修复】强制状态为“待签发/草稿”，确保能被保存过滤器捕获
-    adviceDefinitionId: rowData.adviceDefinitionId // 确保这个字段有值，后端会根据这个字段过滤空行
-  };
-  prescription.prescriptionList[rowIndex.value].orgId = undefined;
-  prescription.prescriptionList[rowIndex.value].dose = undefined;
-  prescription.prescriptionList[rowIndex.value].unitCodeList = unitCodeList.value;
-  prescription.prescriptionList[rowIndex.value].doseUnitCode = row.doseUnitCode;
-  prescription.prescriptionList[rowIndex.value].minUnitCode = row.minUnitCode;
-  prescription.prescriptionList[rowIndex.value].unitCode =
-    row.partAttributeEnum == 1 ? row.minUnitCode : row.unitCode;
-  prescription.prescriptionList[rowIndex.value].definitionId = JSON.parse(
-    JSON.stringify(row)
-  ).chargeItemDefinitionId;
-
-  // 库存列表 + 价格列表拼成批次号的下拉框
+  Object.assign(existingRow, rowData);
+  existingRow.uniqueKey = pk; existingRow.isEdit = pe; existingRow.groupId = pg;
+  existingRow.statusEnum = 1; existingRow.showPopover = false;
+  existingRow.adviceDefinitionId = rowData.adviceDefinitionId;
+  existingRow.orgId = undefined; existingRow.dose = undefined;
+  existingRow.unitCodeList = unitCodeList.value;
+  existingRow.doseUnitCode = row.doseUnitCode;
+  existingRow.minUnitCode = row.minUnitCode;
+  existingRow.unitCode = row.partAttributeEnum == 1 ? row.minUnitCode : row.unitCode;
+  existingRow.definitionId = JSON.parse(JSON.stringify(row)).chargeItemDefinitionId;
   if (row.adviceType == 1 || row.adviceType == 2) {
     if (row.inventoryList && row.inventoryList.length == 0) {
-      prescription.expandOrder = [];
-      proxy.$modal.msgWarning('该项目无库存');
-      return;
+      prescription.expandOrder = []; proxy.$modal.msgWarning("无库存"); return;
     }
-    stockList.value = row.inventoryList.map((item, index) => {
-      return { ...item, ...row.priceList[index] };
-    });
-    prescription.prescriptionList[rowIndex.value].stockList = stockList.value;
-    // 获取默认批次号的库存，如果没有让医生重新选
-    let stock = stockList.value.filter((item) => {
-      return item.lotNumber == row.defaultLotNumber;
-    })[0];
-    if (stock != {} && stock != undefined) {
-      if (stock.quantity <= 0) {
-        proxy.$modal.msgWarning('该项目库存不足，请选择其它库房');
-        // return;
-      }
-      prescription.prescriptionList[rowIndex.value].lotNumber = stock.lotNumber;
-      prescription.prescriptionList[rowIndex.value].inventoryId = stock.inventoryId;
-      prescription.prescriptionList[rowIndex.value].locationId = stock.locationId;
-      prescription.prescriptionList[rowIndex.value].unitPrice = stock.price;
-      prescription.prescriptionList[rowIndex.value].positionName = stock.locationName;
+    stockList.value = row.inventoryList.map((item, i) => ({ ...item, ...row.priceList[i] }));
+    existingRow.stockList = stockList.value;
+    const s = stockList.value.filter(it => it.lotNumber == row.defaultLotNumber)[0];
+    if (s && Object.keys(s).length > 0) {
+      if (s.quantity <= 0) proxy.$modal.msgWarning("库存不足");
+      existingRow.lotNumber = s.lotNumber; existingRow.inventoryId = s.inventoryId;
+      existingRow.locationId = s.locationId; existingRow.unitPrice = s.price;
+      existingRow.positionName = s.locationName;
     }
   } else {
-    prescription.prescriptionList[rowIndex.value].orgId = JSON.parse(
-      JSON.stringify(row)
-    ).positionId;
-    prescription.prescriptionList[rowIndex.value].unitPrice = row.priceList[0].price;
+    existingRow.orgId = JSON.parse(JSON.stringify(row)).positionId;
+    existingRow.unitPrice = row.priceList[0].price;
   }
   prescription.expandOrder = [key];
   nextTick(() => {
+    const t = tableRefs.value[pIndex];
+    if (t && t.setRowExpand) t.setRowExpand([existingRow], true);
     if (row.adviceType == 1) {
-      if (row.injectFlag == 1) {
-        inputRefs.value['executeNum']?.focus();
-      } else {
-        inputRefs.value['dose']?.focus();
-      }
-    } else {
-      inputRefs.value['quantity']?.focus();
-    }
+      row.injectFlag == 1 ? inputRefs.value.executeNum?.focus() : inputRefs.value.dose?.focus();
+    } else { inputRefs.value.quantity?.focus(); }
   });
 }
 
@@ -1246,6 +1141,12 @@ function handleSaveSign(row, index, pIndex) {
       }
 
       row.contentJson = JSON.stringify(row);
+      // 强制刷新数组引用，触发 vxe-table 重渲染（切换只读模式 + 关闭展开行）
+      prescription.prescriptionList = [...prescription.prescriptionList];
+        nextTick(() => {
+          const t = tableRefs.value[pIndex];
+          if (t && t.clearRowExpand) t.clearRowExpand();
+        });
     }
   });
 }
@@ -1345,6 +1246,8 @@ function escKeyListener(e) {
       }
       prescription.prescriptionList.shift();
       prescription.isAdding = false;
+      // 强制刷新数组引用，触发 vxe-table 重渲染
+      prescription.prescriptionList = [...prescription.prescriptionList];
     }
   }
 }