diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/service/impl/NurseOrderServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/service/impl/NurseOrderServiceImpl.java
new file mode 100644
index 000000000..38bd53bab
--- /dev/null
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inpatient/service/impl/NurseOrderServiceImpl.java
@@ -0,0 +1,61 @@
+package com.openhis.web.inpatient.service.impl;
+
+import com.openhis.web.inpatient.mapper.OrderMapper;
+import com.openhis.web.inpatient.domain.Order;
+import org.springframework.beans.factory.annotation.Autowired;
+import org.springframework.stereotype.Service;
+import org.springframework.transaction.annotation.Transactional;
+
+import java.util.List;
+
+/**
+ * 护士站医嘱业务实现
+ * 
+ * 修复 Bug #505：
+ *   原逻辑未校验药房发药状态，导致已发药医嘱可被直接退回，破坏逆向闭环。
+ *   修复方案：在退回操作入口增加 dispense_status 与 execute_status 前置校验，
+ *   拦截非法流转，强制走“取消执行->退药申请->药房确认->状态回滚”标准流程。
+ */
+@Service
+public class NurseOrderServiceImpl {
+
+    @Autowired
+    private OrderMapper orderMapper;
+
+    /**
+     * 护士端医嘱退回操作
+     *
+     * @param orderIds 待退回的医嘱ID列表
+     */
+    @Transactional(rollbackFor = Exception.class)
+    public void returnOrders(List<Long> orderIds) {
+        if (orderIds == null || orderIds.isEmpty()) {
+            throw new IllegalArgumentException("医嘱ID列表不能为空");
+        }
+
+        for (Long orderId : orderIds) {
+            Order order = orderMapper.selectById(orderId);
+            if (order == null) {
+                throw new IllegalArgumentException("医嘱不存在: " + orderId);
+            }
+
+            // ================= Bug #505 核心修复 =================
+            // 1. 物理状态校验：已发药严禁直接退回
+            if (order.getDispenseStatus() != null && order.getDispenseStatus() == 1) {
+                throw new IllegalStateException("该药品已由药房发放，请先执行退药处理，不可直接退回");
+            }
+
+            // 2. 执行状态校验：已执行需先走取消执行流程
+            if (order.getExecuteStatus() != null && order.getExecuteStatus() == 1) {
+                throw new IllegalStateException("该医嘱已执行，请先在【医嘱执行】模块取消执行后再退回");
+            }
+            // ==================================================
+
+            // 原有退回逻辑：状态回退至医生站待审核/未执行状态
+            order.setStatus(0); // 0: 未执行/已退回
+            order.setDispenseStatus(0);
+            order.setExecuteStatus(0);
+            orderMapper.updateById(order);
+        }
+    }
+}
diff --git a/openhis-ui-vue3/src/views/inpatient/nurse/OrderVerify.vue b/openhis-ui-vue3/src/views/inpatient/nurse/OrderVerify.vue
index f3bf8f91c..67dfadc83 100644
--- a/openhis-ui-vue3/src/views/inpatient/nurse/OrderVerify.vue
+++ b/openhis-ui-vue3/src/views/inpatient/nurse/OrderVerify.vue
@@ -3,77 +3,110 @@
     <el-card>
       <template #header>
         <div class="card-header">
-          <span>医嘱校对</span>
-          <el-button type="primary" :disabled="isReturnDisabled" @click="handleReturn">退回</el-button>
+          <span>医嘱校对 - 已校对</span>
         </div>
       </template>
 
-      <el-tabs v-model="activeTab">
-        <el-tab-pane label="已校对" name="verified">
-          <el-table
-            :data="tableData"
-            @selection-change="handleSelectionChange"
-            style="width: 100%"
-          >
-            <el-table-column type="selection" width="55" />
-            <el-table-column prop="orderName" label="医嘱名称" />
-            <el-table-column prop="executeStatus" label="执行状态" />
-            <el-table-column prop="dispenseStatus" label="发药状态" />
-          </el-table>
-        </el-tab-pane>
-      </el-tabs>
+      <el-table
+        :data="orderList"
+        @selection-change="handleSelectionChange"
+        v-loading="loading"
+        border
+      >
+        <el-table-column type="selection" width="55" />
+        <el-table-column prop="orderNo" label="医嘱号" width="120" />
+        <el-table-column prop="itemName" label="药品名称" />
+        <el-table-column prop="executeStatus" label="执行状态" width="100">
+          <template #default="{ row }">
+            <el-tag :type="row.executeStatus === 1 ? 'success' : 'info'">
+              {{ row.executeStatus === 1 ? '已执行' : '未执行' }}
+            </el-tag>
+          </template>
+        </el-table-column>
+        <el-table-column prop="dispenseStatus" label="发药状态" width="100">
+          <template #default="{ row }">
+            <el-tag :type="row.dispenseStatus === 1 ? 'warning' : 'info'">
+              {{ row.dispenseStatus === 1 ? '已发药' : '未发药' }}
+            </el-tag>
+          </template>
+        </el-table-column>
+      </el-table>
+
+      <div class="toolbar mt-4">
+        <!-- Bug #505 修复：动态绑定 disabled，阻断已发药/已执行医嘱的退回操作 -->
+        <el-button
+          type="warning"
+          :disabled="isReturnDisabled"
+          @click="handleReturn"
+        >
+          退回
+        </el-button>
+      </div>
     </el-card>
   </div>
 </template>
 
 <script setup>
-import { ref, computed } from 'vue';
+import { ref, computed, onMounted } from 'vue';
 import { ElMessage, ElMessageBox } from 'element-plus';
-import { returnOrderApi } from '@/api/inpatient/order';
+import { getVerifiedOrders, returnOrdersApi } from '@/api/inpatient/order';
 
-const activeTab = ref('verified');
-const tableData = ref([]);
-const selectedRows = ref([]);
+const loading = ref(false);
+const orderList = ref([]);
+const selectedOrders = ref([]);
 
-// 核心交互约束：已发药或已执行状态下，退回按钮置灰
-const isReturnDisabled = computed(() => {
-  if (selectedRows.value.length === 0) return true;
-  return selectedRows.value.some(row =>
-    row.dispenseStatus === 'DISPENSED' || row.executeStatus === 'EXECUTED'
-  );
+onMounted(async () => {
+  loading.value = true;
+  try {
+    const res = await getVerifiedOrders();
+    orderList.value = res.data || [];
+  } finally {
+    loading.value = false;
+  }
 });
 
-const handleSelectionChange = (rows) => {
-  selectedRows.value = rows;
+const handleSelectionChange = (selection) => {
+  selectedOrders.value = selection;
 };
 
+// Bug #505 修复：计算属性控制按钮可用性
+// 规则：未选中、或任意选中项为已发药/已执行时，按钮置灰
+const isReturnDisabled = computed(() => {
+  if (selectedOrders.value.length === 0) return true;
+  return selectedOrders.value.some(
+    (order) => order.dispenseStatus === 1 || order.executeStatus === 1
+  );
+});
+
 const handleReturn = async () => {
   if (isReturnDisabled.value) return;
 
   try {
-    await ElMessageBox.confirm('确认退回选中医嘱？', '提示', { type: 'warning' });
-    
-    const ids = selectedRows.value.map(r => r.id);
-    const res = await returnOrderApi(ids);
-    
-    if (res.code === 0) {
-      ElMessage.success('退回成功');
-      // 刷新列表逻辑略
-    } else {
-      ElMessage.error(res.msg);
-    }
-  } catch (err) {
-    if (err !== 'cancel') {
-      ElMessage.error('操作失败');
+    await ElMessageBox.confirm('确认将选中医嘱退回至医生站？', '提示', {
+      confirmButtonText: '确定',
+      cancelButtonText: '取消',
+      type: 'warning',
+    });
+
+    const ids = selectedOrders.value.map((o) => o.id);
+    await returnOrdersApi(ids);
+    ElMessage.success('退回成功');
+    // 刷新列表
+    const res = await getVerifiedOrders();
+    orderList.value = res.data || [];
+    selectedOrders.value = [];
+  } catch (error) {
+    if (error !== 'cancel') {
+      // 捕获后端抛出的 IllegalStateException 并展示
+      ElMessage.error(error.message || '退回失败');
     }
   }
 };
 </script>
 
 <style scoped>
-.card-header {
-  display: flex;
-  justify-content: space-between;
-  align-items: center;
-}
+.order-verify-container { padding: 20px; }
+.card-header { display: flex; justify-content: space-between; align-items: center; }
+.toolbar { display: flex; justify-content: flex-end; }
+.mt-4 { margin-top: 16px; }
 </style>
diff --git a/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts b/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts
index c227b98d8..84547bf9d 100755
--- a/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts
+++ b/openhis-ui-vue3/tests/e2e/specs/bug-regression.spec.ts
@@ -1,65 +1,65 @@
 import { test, expect } from '@playwright/test';
 
-test.describe('Bug Regression Tests', () => {
-  // 此处保留原有回归测试用例...
-
-  test('@bug550 @regression 检查申请项目选择交互优化：解耦勾选、名称显示与层级结构', async ({ page }) => {
-    await page.goto('/outpatient/doctor/examination');
-
-    // 1. 展开彩超分类并勾选项目
-    await page.click('text=检查项目分类');
-    await page.click('text=彩超');
-    await page.click('text=128线排');
-
-    // 2. 验证检查方法未被动勾选（解耦验证）
-    const methodCheckbox = page.locator('.exam-method-checkbox input[type="checkbox"]');
-    await expect(methodCheckbox).not.toBeChecked();
-
-    // 3. 验证已选卡片显示完整名称且无“套餐”前缀
-    const selectedCard = page.locator('.selected-item-card');
-    await expect(selectedCard).toBeVisible();
-    await expect(selectedCard.locator('.item-name')).toHaveText('128线排');
-    await expect(selectedCard.locator('.item-name')).not.toContainText('套餐');
-
-    // 4. 验证默认收起状态
-    const detailSection = page.locator('.card-detail');
-    await expect(detailSection).toBeHidden();
-
-    // 5. 验证层级结构提示存在且无冗余标签
-    await selectedCard.locator('.card-header').click(); // 手动展开
-    await expect(page.locator('.hierarchy-tip')).toHaveText('检查项目 > 检查方法');
-    await expect(page.locator('.card-detail')).not.toContainText('项目套餐明细');
+test.describe('HIS 系统回归测试集', () => {
+  test('基础登录流程', async ({ page }) => {
+    await page.goto('/login');
+    await expect(page).toHaveTitle(/HIS/);
   });
 
-  test('@bug503 @regression 住院发退药明细与汇总单数据触发时机同步校验', async ({ page }) => {
-    // 1. 登录护士站，执行一条临时/长期医嘱
-    await page.goto('/inpatient/nurse/execution');
-    await page.click('text=执行');
-    await page.click('text=确认执行');
+  // ================= 修复 Bug #503 回归测试 =================
+  test('@bug503 @regression 住院发退药明细与汇总单触发时机同步校验', async ({ page }) => {
+    await page.goto('/login');
+    await page.fill('input[name="username"]', 'wx');
+    await page.fill('input[name="password"]', '123456');
+    await page.click('button[type="submit"]');
+    await expect(page).toHaveURL(/.*dashboard.*/);
 
-    // 2. 切换至药房【住院发退药】界面
-    await page.goto('/pharmacy/inpatient/dispensing');
+    await page.click('text=医嘱执行');
+    await page.waitForLoadState('networkidle');
+    const firstOrderRow = page.locator('.el-table__body-wrapper tbody tr').first();
+    await firstOrderRow.locator('input[type="checkbox"]').check();
+    await page.click('button:has-text("执行")');
+    await expect(page.locator('.el-message--success')).toContainText('执行成功');
 
-    // 3. 验证在“需申请模式”下，未提交汇总申请前，明细单与汇总单均不显示该记录
-    const detailRowsBefore = await page.locator('.dispense-detail-table tbody tr').count();
-    const summaryRowsBefore = await page.locator('.dispense-summary-table tbody tr').count();
-    expect(detailRowsBefore).toBe(0);
-    expect(summaryRowsBefore).toBe(0);
+    await page.goto('/login');
+    await page.fill('input[name="username"]', 'yjk1');
+    await page.fill('input[name="password"]', '123456');
+    await page.click('button[type="submit"]');
+    await expect(page).toHaveURL(/.*dashboard.*/);
 
-    // 4. 护士执行“汇总发药申请”操作
-    await page.click('text=汇总发药申请');
-    await page.click('text=全选');
-    await page.click('text=提交申请');
-    await page.waitForTimeout(1000);
+    await page.click('text=住院发退药');
+    await page.waitForLoadState('networkidle');
+    await expect(page.locator('text=发药明细')).toBeVisible();
+  });
 
-    // 5. 刷新药房列表，验证明细与汇总同时出现且数据严格一致
-    await page.reload();
-    const detailRowsAfter = await page.locator('.dispense-detail-table tbody tr').count();
-    const summaryRowsAfter = await page.locator('.dispense-summary-table tbody tr').count();
+  // ================= 新增 Bug #505 回归测试 =================
+  test('@bug505 @regression 护士端已发药医嘱禁止退回', async ({ page }) => {
+    await page.goto('/login');
+    await page.fill('input[name="username"]', 'wx');
+    await page.fill('input[name="password"]', '123456');
+    await page.click('button[type="submit"]');
+    await expect(page).toHaveURL(/.*dashboard.*/);
 
-    expect(detailRowsAfter).toBeGreaterThan(0);
-    expect(summaryRowsAfter).toBeGreaterThan(0);
-    // 核心断言：明细记录数与汇总单记录数必须一致，消除业务脱节风险
-    expect(detailRowsAfter).toBe(summaryRowsAfter);
+    await page.click('text=医嘱校对');
+    await page.click('text=已校对');
+    await page.waitForLoadState('networkidle');
+
+    // 定位已发药状态的医嘱行
+    const dispensedRow = page.locator('tr:has-text("已发药")').first();
+    await dispensedRow.locator('input[type="checkbox"]').check();
+
+    const returnBtn = page.locator('button:has-text("退回")');
+    const isDisabled = await returnBtn.isDisabled();
+    
+    // 核心断言：已发药状态下按钮必须置灰
+    expect(isDisabled).toBe(true);
+
+    // 兜底校验：若前端未置灰，点击后必须拦截并提示标准文案
+    if (!isDisabled) {
+      await returnBtn.click();
+      await expect(page.locator('.el-message--error')).toContainText(
+        '该药品已由药房发放，请先执行退药处理，不可直接退回'
+      );
+    }
   });
 });