diff --git a/openhis-server-new/core-framework/src/main/java/com/core/framework/config/ApplicationConfig.java b/openhis-server-new/core-framework/src/main/java/com/core/framework/config/ApplicationConfig.java
index 2a699eed..4084f9d9 100644
--- a/openhis-server-new/core-framework/src/main/java/com/core/framework/config/ApplicationConfig.java
+++ b/openhis-server-new/core-framework/src/main/java/com/core/framework/config/ApplicationConfig.java
@@ -1,11 +1,15 @@
 package com.core.framework.config;
 
+import com.fasterxml.jackson.datatype.jsr310.JavaTimeModule;
+import com.fasterxml.jackson.datatype.jsr310.ser.LocalDateTimeSerializer;
 import org.mybatis.spring.annotation.MapperScan;
 import org.springframework.boot.autoconfigure.jackson.Jackson2ObjectMapperBuilderCustomizer;
 import org.springframework.context.annotation.Bean;
 import org.springframework.context.annotation.Configuration;
 import org.springframework.context.annotation.EnableAspectJAutoProxy;
 
+import java.time.LocalDateTime;
+import java.time.format.DateTimeFormatter;
 import java.util.TimeZone;
 
 /**
@@ -24,6 +28,14 @@ public class ApplicationConfig {
      */
     @Bean
     public Jackson2ObjectMapperBuilderCustomizer jacksonObjectMapperCustomization() {
-        return jacksonObjectMapperBuilder -> jacksonObjectMapperBuilder.timeZone(TimeZone.getDefault());
+        return builder -> {
+            // 设置默认时区
+            builder.timeZone(TimeZone.getDefault());
+            // 设置日期格式为 yyyy/M/d HH:mm:ss，支持多种格式反序列化
+            builder.simpleDateFormat("yyyy/M/d HH:mm:ss");
+            // 添加JavaTimeModule支持，用于LocalDateTime
+            builder.modules(new JavaTimeModule());
+            builder.serializerByType(LocalDateTime.class, new LocalDateTimeSerializer(DateTimeFormatter.ofPattern("yyyy/M/d HH:mm:ss")));
+        };
     }
 }
diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationDiagnosisAppServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationDiagnosisAppServiceImpl.java
index cd9f8ce2..eee60abe 100644
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationDiagnosisAppServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationDiagnosisAppServiceImpl.java
@@ -273,12 +273,28 @@ public class DoctorStationDiagnosisAppServiceImpl implements IDoctorStationDiagn
      */
     @Override
     public R<?> saveDoctorDiagnosisNew(SaveDiagnosisParam saveDiagnosisParam) {
+        // 参数校验：确保诊断列表不为空
+        if (saveDiagnosisParam == null) {
+            return R.fail(MessageUtils.message(PromptMsgConstant.Common.M00009, new Object[] { "保存诊断参数" }));
+        }
+        
         // 患者id
         Long patientId = saveDiagnosisParam.getPatientId();
         // 就诊ID
         Long encounterId = saveDiagnosisParam.getEncounterId();
         // 诊断定义集合
         List<SaveDiagnosisChildParam> diagnosisChildList = saveDiagnosisParam.getDiagnosisChildList();
+        
+        // 校验患者ID和就诊ID
+        if (patientId == null || encounterId == null) {
+            return R.fail(MessageUtils.message(PromptMsgConstant.Common.M00009, new Object[] { "患者ID或就诊ID" }));
+        }
+        
+        // 校验诊断列表不为空
+        if (diagnosisChildList == null || diagnosisChildList.isEmpty()) {
+            return R.fail(MessageUtils.message(PromptMsgConstant.Common.M00009, new Object[] { "诊断列表" }));
+        }
+        
         // 先删除再保存
         // iEncounterDiagnosisService.deleteEncounterDiagnosisInfos(encounterId);
 
diff --git a/openhis-ui-vue3/src/views/doctorstation/components/diagnosis/diagnosis.vue b/openhis-ui-vue3/src/views/doctorstation/components/diagnosis/diagnosis.vue
index e45c8343..06a885da 100644
--- a/openhis-ui-vue3/src/views/doctorstation/components/diagnosis/diagnosis.vue
+++ b/openhis-ui-vue3/src/views/doctorstation/components/diagnosis/diagnosis.vue
@@ -280,6 +280,7 @@ import {
   saveDiagnosis,
 } from '../api';
 import { DIAG_TYPE } from '@/utils/medicalConstants';
+import { formatDateStr } from '@/utils';
 import diagnosisdialog from '../diagnosis/diagnosisdialog.vue';
 import AddDiagnosisDialog from './addDiagnosisDialog.vue';
 import diagnosislist from '../diagnosis/diagnosislist.vue';
@@ -628,11 +629,11 @@ async function handleSaveDiagnosis() {
     // 开始加载状态，防止重复提交
     saveLoading.value = true;
 
-    // 保存前按排序号排序，并转换日期格式为ISO字符串
+    // 保存前按排序号排序，并转换日期格式为后端期望的格式 yyyy/M/d HH:mm:ss
     const diagnosisChildList = form.value.diagnosisList.map(item => ({
       ...item,
-      onsetDate: item.onsetDate ? new Date(item.onsetDate).toISOString() : null,
-      diagnosisTime: item.diagnosisTime ? new Date(item.diagnosisTime).toISOString() : null
+      onsetDate: item.onsetDate ? formatDateStr(item.onsetDate, 'YYYY/M/D HH:mm:ss') : null,
+      diagnosisTime: item.diagnosisTime ? formatDateStr(item.diagnosisTime, 'YYYY/M/D HH:mm:ss') : null
     }));
 
     // 调用保存诊断接口
@@ -657,7 +658,9 @@ async function handleSaveDiagnosis() {
     }
   } catch (error) {
     console.error('保存诊断失败:', error);
-    proxy.$modal.msgError('保存诊断失败，请稍后重试');
+    // 显示后端返回的具体错误信息
+    const errorMsg = error?.response?.data?.msg || error?.message || '保存诊断失败，请稍后重试';
+    proxy.$modal.msgError(errorMsg);
   } finally {
     // 结束加载状态
     saveLoading.value = false;