diff --git a/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue b/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue
index 6908d51e7..865efff9b 100755
--- a/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue
+++ b/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue
@@ -926,23 +926,36 @@ function handleDelete() {
   }
   
   if (hasSavedItem) {
-    // 有已保存的行，调用后端API删除
-    savePrescription({ adviceSaveList: deleteList }).then((res) => {
-      if (res.code == 200) {
-        proxy.$modal.msgSuccess('操作成功');
-        getListInfo(false);
-      }
+    // 🔧 Bug #454: 删除前弹出确认提示，告知用户将级联删除关联检验申请单
+    const hasLabItem = deleteList.some(item => item.adviceType === 3);
+    const confirmMsg = hasLabItem
+      ? '删除此医嘱将同时删除关联的检验申请单，是否确认删除？'
+      : '确认删除选中的医嘱项目吗？';
+
+    proxy.$modal.confirm(confirmMsg).then(() => {
+      savePrescription({ adviceSaveList: deleteList }).then((res) => {
+        if (res.code == 200) {
+          proxy.$modal.msgSuccess('操作成功');
+          getListInfo(false);
+          expandOrder.value = [];
+          groupIndexList.value = [];
+          groupList.value = [];
+          isAdding.value = false;
+          adviceQueryParams.value.adviceType = undefined;
+        }
+      });
+    }).catch(() => {
+      // 用户取消删除
     });
   } else {
     // 只有新增行，已经在前端删除完成
     proxy.$modal.msgSuccess('操作成功');
+    expandOrder.value = [];
+    groupIndexList.value = [];
+    groupList.value = [];
+    isAdding.value = false;
+    adviceQueryParams.value.adviceType = undefined;
   }
-  
-  expandOrder.value = [];
-  groupIndexList.value = [];
-  groupList.value = [];
-  isAdding.value = false;
-  adviceQueryParams.value.adviceType = undefined;
 }
 
 function handleNumberClick(item, index) {