diff --git a/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue b/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue
index 9101399f..39dbab7f 100644
--- a/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue
+++ b/openhis-ui-vue3/src/views/clinicmanagement/bargain/component/prescriptionlist.vue
@@ -383,6 +383,7 @@ const props = defineProps({
   },
 });
 const isAdding = ref(false);
+const isSaving = ref(false); // #437 防重复提交锁
 const prescriptionRef = ref();
 const expandOrder = ref([]); //目前的展开行
 const stockList = ref([]);
@@ -1028,13 +1029,18 @@ function handleSave() {
       })
       groupIndexList.value = []
       groupList.value = []
-      nextId.value == 1;
+      nextId.value = 1;
     }
   });
 }
 
 // 单行处方保存
 function handleSaveSign(row, index) {
+  // 🔧 Bug Fix #437: 防重复提交锁
+  if (isSaving.value) {
+    proxy.$modal.msgWarning('正在保存中，请勿重复提交');
+    return;
+  }
   // 🔧 Bug Fix #238: 诊疗项目必须选择执行科室
   if (row.adviceType === 3 && !row.orgId) {
     proxy.$modal.msgWarning('诊疗项目必须选择执行科室');
@@ -1042,33 +1048,37 @@ function handleSaveSign(row, index) {
   }
   proxy.$refs['formRef' + index].validate((valid) => {
     if (valid) {
+      isSaving.value = true; // #437 加锁
       row.isEdit = false;
       isAdding.value = false;
       expandOrder.value = [];
       row.patientId = props.patientInfo.patientId;
       row.encounterId = props.patientInfo.encounterId;
       row.accountId = props.patientInfo.accountId;
-      row.contentJson = JSON.stringify(row);
-      row.dbOpType = row.requestId ? '2' : '1';
-      row.minUnitQuantity = row.quantity * row.partPercent;
-      row.categoryEnum = row.adviceType
+      const cleanRow = JSON.parse(JSON.stringify(row));
+      cleanRow.contentJson = JSON.stringify(cleanRow);
+      cleanRow.dbOpType = cleanRow.requestId ? '2' : '1';
+      cleanRow.minUnitQuantity = cleanRow.quantity * cleanRow.partPercent;
+      cleanRow.categoryEnum = cleanRow.adviceType
       // 如果是手术计费，设置生成来源和来源业务单据号
       if (props.patientInfo.sourceBillNo) {
-        row.generateSourceEnum = 6; // 手术计费
-        row.sourceBillNo = props.patientInfo.sourceBillNo;
+        cleanRow.generateSourceEnum = 6; // 手术计费
+        cleanRow.sourceBillNo = props.patientInfo.sourceBillNo;
       }
-      console.log('row', row)
-      savePrescription({ adviceSaveList: [row] }).then((res) => {
+      console.log('cleanRow', cleanRow)
+      savePrescription({ adviceSaveList: [cleanRow] }).then((res) => {
         if (res.code === 200) {
           proxy.$modal.msgSuccess('保存成功');
           getListInfo(false);
-          nextId.value == 1;
+          nextId.value = 1;
           // 🔧 Bug Fix #238: 如果诊疗项目缺少执行科室，标记为需要修复的脏数据
           if (row.adviceType === 3 && !row.orgId) {
-            console.warn('Bug #238: 检测到诊疗项目保存时缺少执行科室，请手动编辑修正:', row);
+            console.warn('Bug #238: 检测到诊疗项目保存时缺少执行科室，请手动编辑修正:', cleanRow);
             proxy.$modal.msgWarning('诊疗项目执行科室信息不完整，请编辑后重新保存');
           }
         }
+      }).finally(() => {
+        isSaving.value = false; // #437 释放锁
       });
     }
   });