diff --git a/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/doctorstation/appservice/impl/DoctorStationChineseMedicalAppServiceImpl.java b/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/doctorstation/appservice/impl/DoctorStationChineseMedicalAppServiceImpl.java
index c41c6a5d9..30e69da75 100755
--- a/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/doctorstation/appservice/impl/DoctorStationChineseMedicalAppServiceImpl.java
+++ b/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/doctorstation/appservice/impl/DoctorStationChineseMedicalAppServiceImpl.java
@@ -614,8 +614,12 @@ public class DoctorStationChineseMedicalAppServiceImpl implements IDoctorStation
         Long encounterDiagnosisId = medicineList.get(0).getEncounterDiagnosisId();
         // 中药付数
         BigDecimal chineseHerbsDoseQuantity = medicineList.get(0).getChineseHerbsDoseQuantity();
-        // 处方号
-        String prescriptionNo = insertOrUpdateList.get(0).getPrescriptionNo();
+        // 🔧 Bug Fix #668: 收集所有处方号（不同分组可能有不同处方号）
+        List<String> prescriptionNos = insertOrUpdateList.stream()
+                .map(AdviceSaveDto::getPrescriptionNo)
+                .filter(Objects::nonNull)
+                .distinct()
+                .collect(Collectors.toList());
 
         // 签发时,生成中药代煎的账单
         if (Whether.YES.getValue().equals(sufferingFlag) && is_sign) {
@@ -624,9 +628,12 @@ public class DoctorStationChineseMedicalAppServiceImpl implements IDoctorStation
             AdviceBaseDto adviceBaseDto = new AdviceBaseDto();
             adviceBaseDto.setAdviceDefinitionId(sufferingDefinitionId); // 医嘱定义id
 
-            // 先删除中药代煎的账单
-            iChargeItemService.remove(new LambdaQueryWrapper<ChargeItem>()
-                    .eq(ChargeItem::getPrescriptionNo, prescriptionNo).eq(ChargeItem::getProductId, sufferingDefinitionId));
+            // 🔧 Bug Fix #668: 先删除所有处方号关联的中药代煎账单
+            if (!prescriptionNos.isEmpty()) {
+                iChargeItemService.remove(new LambdaQueryWrapper<ChargeItem>()
+                        .in(ChargeItem::getPrescriptionNo, prescriptionNos)
+                        .eq(ChargeItem::getProductId, sufferingDefinitionId));
+            }
 
             // 对应的诊疗医嘱信息
             AdviceBaseDto activityAdviceBaseDto = iDoctorStationAdviceAppService.getAdviceBaseInfo(adviceBaseDto, null,
@@ -635,40 +642,44 @@ public class DoctorStationChineseMedicalAppServiceImpl implements IDoctorStation
                 // 费用定价
                 AdvicePriceDto advicePriceDto = activityAdviceBaseDto.getPriceList().get(0);
                 if (advicePriceDto != null) {
-                    // 生成账单
-                    chargeItem = new ChargeItem();
-                    chargeItem.setGenerateSourceEnum(GenerateSource.DOCTOR_PRESCRIPTION.getValue()); // 生成来源
-                    chargeItem.setPrescriptionNo(prescriptionNo); // 处方号
-                    chargeItem.setStatusEnum(ChargeItemStatus.PLANNED.getValue()); // 收费状态
-                    chargeItem.setBusNo(assignSeqUtil.getSeqByDay(AssignSeqEnum.CHARGE_ITEM_NO.getPrefix(), 4));
-                    chargeItem.setGenerateSourceEnum(GenerateSource.DOCTOR_PRESCRIPTION.getValue()); // 生成来源
-                    chargeItem.setPatientId(patientId); // 患者
-                    chargeItem.setContextEnum(ChargeItemContext.ACTIVITY.getValue()); // 类型
-                    chargeItem.setEncounterId(encounterId); // 就诊id
-                    chargeItem.setDefinitionId(advicePriceDto.getDefinitionId()); // 费用定价ID
-                    chargeItem.setEntererId(SecurityUtils.getLoginUser().getPractitionerId());// 开立人ID
-                    chargeItem.setRequestingOrgId(orgId); // 开立科室
-                    chargeItem.setEnteredDate(curDate); // 开立时间
-                    chargeItem.setProductTable(activityAdviceBaseDto.getAdviceTableName());// 产品所在表
-                    chargeItem.setProductId(activityAdviceBaseDto.getAdviceDefinitionId());// 收费项id
-                    chargeItem.setAccountId(accountId);// 关联账户ID
-                    chargeItem.setConditionId(conditionId); // 诊断id
-                    chargeItem.setEncounterDiagnosisId(encounterDiagnosisId); // 就诊诊断id
+                    // 🔧 Bug Fix #668: 为每个处方号分别生成代煎账单
+                    for (String prescriptionNo : prescriptionNos) {
+                        chargeItem = new ChargeItem();
+                        chargeItem.setGenerateSourceEnum(GenerateSource.DOCTOR_PRESCRIPTION.getValue()); // 生成来源
+                        chargeItem.setPrescriptionNo(prescriptionNo); // 处方号
+                        chargeItem.setStatusEnum(ChargeItemStatus.PLANNED.getValue()); // 收费状态
+                        chargeItem.setBusNo(assignSeqUtil.getSeqByDay(AssignSeqEnum.CHARGE_ITEM_NO.getPrefix(), 4));
+                        chargeItem.setPatientId(patientId); // 患者
+                        chargeItem.setContextEnum(ChargeItemContext.ACTIVITY.getValue()); // 类型
+                        chargeItem.setEncounterId(encounterId); // 就诊id
+                        chargeItem.setDefinitionId(advicePriceDto.getDefinitionId()); // 费用定价ID
+                        chargeItem.setEntererId(SecurityUtils.getLoginUser().getPractitionerId());// 开立人ID
+                        chargeItem.setRequestingOrgId(orgId); // 开立科室
+                        chargeItem.setEnteredDate(curDate); // 开立时间
+                        chargeItem.setProductTable(activityAdviceBaseDto.getAdviceTableName());// 产品所在表
+                        chargeItem.setProductId(activityAdviceBaseDto.getAdviceDefinitionId());// 收费项id
+                        chargeItem.setAccountId(accountId);// 关联账户ID
+                        chargeItem.setConditionId(conditionId); // 诊断id
+                        chargeItem.setEncounterDiagnosisId(encounterDiagnosisId); // 就诊诊断id
 
-                    chargeItem.setQuantityValue(quantity); // 数量
-                    chargeItem.setQuantityUnit(activityAdviceBaseDto.getUnitCode()); // 单位
-                    chargeItem.setUnitPrice(advicePriceDto.getPrice()); // 单价
-                    // 计算总价,保留6位小数
-                    BigDecimal qty = quantity;
-                    chargeItem.setTotalPrice(qty.multiply(advicePriceDto.getPrice()).setScale(6, RoundingMode.HALF_UP)); // 总价
-                    chargeItem.setTcmFlag(Whether.YES.getValue());// 中医标识
-                    iChargeItemService.save(chargeItem);
+                        chargeItem.setQuantityValue(quantity); // 数量
+                        chargeItem.setQuantityUnit(activityAdviceBaseDto.getUnitCode()); // 单位
+                        chargeItem.setUnitPrice(advicePriceDto.getPrice()); // 单价
+                        // 计算总价,保留6位小数
+                        BigDecimal qty = quantity;
+                        chargeItem.setTotalPrice(qty.multiply(advicePriceDto.getPrice()).setScale(6, RoundingMode.HALF_UP)); // 总价
+                        chargeItem.setTcmFlag(Whether.YES.getValue());// 中医标识
+                        iChargeItemService.save(chargeItem);
+                    }
                 }
             }
         } else if (Whether.NO.getValue().equals(sufferingFlag)) {
-            // 删除中药代煎的账单
-            iChargeItemService.remove(new LambdaQueryWrapper<ChargeItem>()
-                    .eq(ChargeItem::getPrescriptionNo, prescriptionNo).eq(ChargeItem::getProductId, sufferingDefinitionId));
+            // 🔧 Bug Fix #668: 删除所有处方号关联的中药代煎账单
+            if (!prescriptionNos.isEmpty()) {
+                iChargeItemService.remove(new LambdaQueryWrapper<ChargeItem>()
+                        .in(ChargeItem::getPrescriptionNo, prescriptionNos)
+                        .eq(ChargeItem::getProductId, sufferingDefinitionId));
+            }
         }
 
         // 签发时,把草稿状态的账单更新为待收费[中医]