diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/AdviceManageAppServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/AdviceManageAppServiceImpl.java
index 957313188..26afdbcd2 100755
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/AdviceManageAppServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/regdoctorstation/appservice/impl/AdviceManageAppServiceImpl.java
@@ -710,11 +710,21 @@ public class AdviceManageAppServiceImpl implements IAdviceManageAppService {
 
         // 批量更新诊疗医嘱状态（使用 update 确保状态字段必定更新）
         if (!processedRequestIds.isEmpty()) {
-            iServiceRequestService.update(null,
-                    new LambdaUpdateWrapper<ServiceRequest>()
-                            .set(ServiceRequest::getStatusEnum,
-                                    is_save ? RequestStatus.DRAFT.getValue() : RequestStatus.ACTIVE.getValue())
-                            .in(ServiceRequest::getId, processedRequestIds));
+            // 🔧 Bug #487 修复：签发时额外设置 authoredTime，确保签发时间被记录
+            if (is_sign) {
+                iServiceRequestService.update(null,
+                        new LambdaUpdateWrapper<ServiceRequest>()
+                                .set(ServiceRequest::getStatusEnum, RequestStatus.ACTIVE.getValue())
+                                .set(ServiceRequest::getAuthoredTime, authoredTime)
+                                .set(ServiceRequest::getSignCode, signCode)
+                                .in(ServiceRequest::getId, processedRequestIds));
+                log.info("签发诊疗医嘱成功，requestIds: {}, signCode: {}", processedRequestIds, signCode);
+            } else {
+                iServiceRequestService.update(null,
+                        new LambdaUpdateWrapper<ServiceRequest>()
+                                .set(ServiceRequest::getStatusEnum, RequestStatus.DRAFT.getValue())
+                                .in(ServiceRequest::getId, processedRequestIds));
+            }
         }
     }
 
diff --git a/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue b/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue
index 2db56ab37..dd7fc8794 100755
--- a/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue
+++ b/openhis-ui-vue3/src/views/inpatientDoctor/home/components/order/index.vue
@@ -1241,6 +1241,13 @@ function handleSave() {
         if (res.code === 200) {
           proxy.$modal.msgSuccess('签发成功');
           isSaving.value = false;
+          // 乐观更新：立即将已签发医嘱的状态设为"已签发"，确保列表实时刷新
+          saveList.forEach((item) => {
+            const row = prescriptionList.value.find((r) => r.requestId && r.requestId === item.requestId);
+            if (row) {
+              row.statusEnum = 2;
+            }
+          });
           getListInfo(false);
           bindMethod.value = {};
           nextId.value = 1;