diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inventorymanage/appservice/impl/RequisitionIssueAppServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inventorymanage/appservice/impl/RequisitionIssueAppServiceImpl.java
index ed0af2260..33888bab9 100755
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inventorymanage/appservice/impl/RequisitionIssueAppServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/inventorymanage/appservice/impl/RequisitionIssueAppServiceImpl.java
@@ -256,6 +256,9 @@ public class RequisitionIssueAppServiceImpl implements IRequisitionIssueAppServi
      */
     @Override
     public R<?> submitApproval(String busNo) {
+        // 提交审批前校验库存，防止超库存单据进入审批流
+        this.validateRequisitionStockByBusNo(busNo);
+
         // 单据提交审核
         boolean result = supplyRequestService.submitApproval(busNo);
         return result ? R.ok(null, MessageUtils.createMessage(PromptMsgConstant.Common.M00004, null))
@@ -419,4 +422,80 @@ public class RequisitionIssueAppServiceImpl implements IRequisitionIssueAppServi
             }
         }
     }
+
+    /**
+     * 根据单据号校验领用数量是否超过源仓库实际库存（提交审批前调用）
+     *
+     * @param busNo 单据号
+     */
+    private void validateRequisitionStockByBusNo(String busNo) {
+        Integer tenantId = SecurityUtils.getLoginUser().getTenantId();
+        // 通过单据详情查询已保存的单据明细
+        R<List<IssueDetailDto>> detailResult = this.getDetail(busNo);
+        if (detailResult.getCode() != 200 || detailResult.getData() == null) {
+            return;
+        }
+        List<IssueDetailDto> detailList = detailResult.getData();
+        for (IssueDetailDto detail : detailList) {
+            Long itemId = detail.getItemId();
+            String lotNumber = detail.getLotNumber();
+            Long sourceLocationId = detail.getSourceLocationId();
+            BigDecimal reqQuantity = detail.getItemQuantity();
+            String itemTable = CommonConstants.TableName.MED_MEDICATION_DEFINITION;
+            // 根据药品类型判断表名
+            if (ItemType.DEVICE.getValue().equals(detail.getItemType())) {
+                itemTable = CommonConstants.TableName.ADM_DEVICE_DEFINITION;
+            }
+
+            // 查询定义信息（拆零比、单位）
+            BigDecimal partPercent = BigDecimal.ONE;
+            String unitCode = detail.getUnitCode();
+            String minUnitCode = detail.getMinUnitCode();
+
+            if (CommonConstants.TableName.MED_MEDICATION_DEFINITION.equals(itemTable)) {
+                MedicationDefinition medDef = medicationDefinitionService.getById(itemId);
+                if (medDef != null) {
+                    unitCode = medDef.getUnitCode();
+                    minUnitCode = medDef.getMinUnitCode();
+                    if (medDef.getPartPercent() != null) {
+                        partPercent = medDef.getPartPercent();
+                    }
+                }
+            } else if (CommonConstants.TableName.ADM_DEVICE_DEFINITION.equals(itemTable)) {
+                DeviceDefinition devDef = deviceDefinitionService.getById(itemId);
+                if (devDef != null) {
+                    unitCode = devDef.getUnitCode();
+                    minUnitCode = devDef.getMinUnitCode();
+                    if (devDef.getPartPercent() != null) {
+                        partPercent = devDef.getPartPercent();
+                    }
+                }
+            }
+
+            // 计算领用数量折合最小单位的值
+            BigDecimal reqQuantityInMinUnit;
+            if (unitCode != null && detail.getUnitCode().equals(unitCode)) {
+                reqQuantityInMinUnit = reqQuantity.multiply(partPercent);
+            } else {
+                reqQuantityInMinUnit = reqQuantity;
+            }
+
+            // 查询源仓库实际库存
+            List<InventoryItem> inventoryItemList = inventoryItemService.selectInventoryByItemId(
+                    itemId, lotNumber, sourceLocationId, tenantId);
+
+            // 累加总库存
+            BigDecimal totalStock = BigDecimal.ZERO;
+            for (InventoryItem inventoryItem : inventoryItemList) {
+                if (inventoryItem.getLocationId().equals(sourceLocationId)) {
+                    totalStock = totalStock.add(inventoryItem.getQuantity());
+                }
+            }
+
+            // 比较领用数量与库存
+            if (reqQuantityInMinUnit.compareTo(totalStock) > 0) {
+                throw new ServiceException("提交失败，单据中存在领用数量超过库存的明细，请核对后重新保存");
+            }
+        }
+    }
 }
diff --git a/openhis-ui-vue3/src/views/medicationmanagement/requisitionManagement/requisitionManagement/index.vue b/openhis-ui-vue3/src/views/medicationmanagement/requisitionManagement/requisitionManagement/index.vue
index 1d56b6da6..02c6df268 100755
--- a/openhis-ui-vue3/src/views/medicationmanagement/requisitionManagement/requisitionManagement/index.vue
+++ b/openhis-ui-vue3/src/views/medicationmanagement/requisitionManagement/requisitionManagement/index.vue
@@ -982,6 +982,16 @@ function handleSubmitApproval() {
   } else if (!form.purchaseinventoryList[length - 1].isSave) {
     proxy.$modal.msgWarning('第' + length + '行单据未保存，请先保存');
   } else {
+    // 提交审批前逐行校验库存，防止超库存单据进入审批
+    for (let i = 0; i < form.purchaseinventoryList.length; i++) {
+      const line = form.purchaseinventoryList[i];
+      if (!line) continue;
+      const err = validateRequisitionQtyVsStock(line, i + 1);
+      if (err) {
+        proxy.$modal.msgWarning(err);
+        return;
+      }
+    }
     submitApproval(receiptHeaderForm.busNo).then((response) => {
       if (response.code == 200) {
         proxy.$modal.msgSuccess('提交审批成功');