diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/lab/appservice/impl/LabActivityDefinitionAppServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/lab/appservice/impl/LabActivityDefinitionAppServiceImpl.java
index 39b3b001..93b2b3a1 100644
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/lab/appservice/impl/LabActivityDefinitionAppServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/lab/appservice/impl/LabActivityDefinitionAppServiceImpl.java
@@ -17,6 +17,7 @@ import com.openhis.common.utils.HisQueryUtils;
 import com.openhis.common.enums.AssignSeqEnum;
 import com.openhis.lab.domain.LabActivityDefinition;
 import com.openhis.lab.service.ILabActivityDefinitionService;
+import java.math.BigDecimal;
 import com.openhis.web.datadictionary.dto.DiagnosisTreatmentDto;
 import com.openhis.web.datadictionary.dto.DiagnosisTreatmentSelParam;
 import com.openhis.web.datadictionary.dto.DiagnosisTreatmentUpDto;
@@ -84,6 +85,13 @@ public class LabActivityDefinitionAppServiceImpl implements ILabActivityDefiniti
                 .getLabActivityDefinitionPage(new Page<>(pageNo, pageSize), queryWrapper);
 
         page.getRecords().forEach(e -> {
+            // Fix for Bug #415: Ensure prices are not negative
+            if (e.getPackageAmount() != null && e.getPackageAmount().compareTo(BigDecimal.ZERO) < 0) {
+                e.setPackageAmount(BigDecimal.ZERO);
+            }
+            if (e.getServiceFee() != null && e.getServiceFee().compareTo(BigDecimal.ZERO) < 0) {
+                e.setServiceFee(BigDecimal.ZERO);
+            }
             e.setYbFlag_enumText(EnumUtils.getInfoByValue(Whether.class, e.getYbFlag()));
             e.setYbMatchFlag_enumText(EnumUtils.getInfoByValue(Whether.class, e.getYbMatchFlag()));
             e.setTypeEnum_enumText(EnumUtils.getInfoByValue(ActivityType.class, e.getTypeEnum()));
@@ -98,6 +106,15 @@ public class LabActivityDefinitionAppServiceImpl implements ILabActivityDefiniti
     public R<?> getLabActivityDefinitionOne(Long id) {
         Integer tenantId = SecurityUtils.getLoginUser().getTenantId();
         DiagnosisTreatmentDto dto = labActivityDefinitionManageMapper.getLabActivityDefinitionOne(id, tenantId);
+        // Fix for Bug #415: Ensure prices are not negative for single item
+        if (dto != null) {
+            if (dto.getPackageAmount() != null && dto.getPackageAmount().compareTo(BigDecimal.ZERO) < 0) {
+                dto.setPackageAmount(BigDecimal.ZERO);
+            }
+            if (dto.getServiceFee() != null && dto.getServiceFee().compareTo(BigDecimal.ZERO) < 0) {
+                dto.setServiceFee(BigDecimal.ZERO);
+            }
+        }
         return R.ok(dto);
     }