diff --git a/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/regdoctorstation/utils/RegPrescriptionUtils.java b/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/regdoctorstation/utils/RegPrescriptionUtils.java
index 1a5dcae06..83a499a85 100755
--- a/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/regdoctorstation/utils/RegPrescriptionUtils.java
+++ b/healthlink-his-server/healthlink-his-application/src/main/java/com/healthlink/his/web/regdoctorstation/utils/RegPrescriptionUtils.java
@@ -26,9 +26,11 @@ public class RegPrescriptionUtils {
         if (medicineList == null || medicineList.isEmpty()) {
             return;
         }
-        // 1. 按诊断ID分组（不同诊断必须分开）
+        // 1. 按诊断ID分组（不同诊断必须分开，null值归为一组）
         Map<Long, List<RegAdviceSaveDto>> diagnosisGroups =
-            medicineList.stream().collect(Collectors.groupingBy(RegAdviceSaveDto::getConditionDefinitionId));
+            medicineList.stream().collect(Collectors.groupingBy(dto ->
+                dto.getConditionDefinitionId() != null ? dto.getConditionDefinitionId() : 0L
+            ));
         // 2. 处理每个诊断组
         diagnosisGroups.values().forEach(this::processDiagnosisGroup);
     }
@@ -40,14 +42,18 @@ public class RegPrescriptionUtils {
         if (diagnosisGroup.isEmpty()) {
             return;
         }
-        // 1. 按药品性质分组
+        // 1. 按药品性质分组（null值归为普通药品）
         Map<String, List<RegAdviceSaveDto>> pharmacologyGroups =
-            diagnosisGroup.stream().collect(Collectors.groupingBy(RegAdviceSaveDto::getPharmacologyCategoryCode));
+            diagnosisGroup.stream().collect(Collectors.groupingBy(dto ->
+                dto.getPharmacologyCategoryCode() != null ? dto.getPharmacologyCategoryCode() : "0"
+            ));
         // 2. 处理每个药品性质组
         pharmacologyGroups.values().forEach(pharmaGroup -> {
             // 2.1 按治疗类型分组
             Map<Integer, List<RegAdviceSaveDto>> therapyGroups =
-                pharmaGroup.stream().collect(Collectors.groupingBy(RegAdviceSaveDto::getTherapyEnum));
+                pharmaGroup.stream().collect(Collectors.groupingBy(dto ->
+                    dto.getTherapyEnum() != null ? dto.getTherapyEnum() : 0
+                ));
             // 2.2 为每组治疗类型生成唯一处方号
             therapyGroups.forEach((therapyEnum, group) -> {
                 String prescriptionNo = generatePrescriptionNo(pharmaGroup.get(0).getPharmacologyCategoryCode());
@@ -60,6 +66,9 @@ public class RegPrescriptionUtils {
      * 根据药品性质生成处方号（前缀规则与原工具类一致）
      */
     private String generatePrescriptionNo(String pharmacologyCategoryCode) {
+        if (pharmacologyCategoryCode == null || pharmacologyCategoryCode.isEmpty()) {
+            return assignSeqUtil.getSeq(AssignSeqEnum.PRESCRIPTION_COMMON_NO.getPrefix(), 8);
+        }
         switch (pharmacologyCategoryCode) {
             case "2": // 麻醉药品
                 return assignSeqUtil.getSeq(AssignSeqEnum.PRESCRIPTION_NARCOTIC_NO.getPrefix(), 8);
@@ -74,4 +83,4 @@ public class RegPrescriptionUtils {
         }
     }
 
-}
+}
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