diff --git a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java
index 6995a5c6..27b7d0fe 100644
--- a/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java
+++ b/openhis-server-new/openhis-application/src/main/java/com/openhis/web/doctorstation/appservice/impl/DoctorStationAdviceAppServiceImpl.java
@@ -140,6 +140,17 @@ public class DoctorStationAdviceAppServiceImpl implements IDoctorStationAdviceAp
             adviceUtils.subtractInventory(adviceInventoryList, adviceDraftInventoryList);
         // 查询取药科室配置
         List<AdviceInventoryDto> medLocationConfig = doctorStationAdviceAppMapper.getMedLocationConfig(organizationId);
+        // 将配置转为 {categoryCode -> 允许的locationId集合}
+        Map<String, Set<Long>> allowedLocByCategory = new HashMap<>();
+        if (medLocationConfig != null && !medLocationConfig.isEmpty()) {
+            for (AdviceInventoryDto cfg : medLocationConfig) {
+                if (cfg.getCategoryCode() == null || cfg.getLocationId() == null) {
+                    continue;
+                }
+                allowedLocByCategory.computeIfAbsent(String.valueOf(cfg.getCategoryCode()), k -> new HashSet<>())
+                    .add(cfg.getLocationId());
+            }
+        }
         // 费用定价子表信息
         List<AdvicePriceDto> childCharge = doctorStationAdviceAppMapper
             .getChildCharge(ConditionCode.LOT_NUMBER_COST.getCode(), chargeItemDefinitionIdList);
@@ -163,6 +174,19 @@ public class DoctorStationAdviceAppServiceImpl implements IDoctorStationAdviceAp
                                 .filter(e -> baseDto.getAdviceDefinitionId().equals(e.getItemId())
                                     && baseDto.getAdviceTableName().equals(e.getItemTable()))
                                 .collect(Collectors.toList());
+                    // 当存在按科室配置时：仅保留被允许的药房/药库的库存；
+                    // 若该药品类别未在配置中出现，则视为不可开立（清空库存以便前端过滤掉）
+                    if (!allowedLocByCategory.isEmpty()) {
+                        Set<Long> allowedLoc =
+                            allowedLocByCategory.get(String.valueOf(baseDto.getCategoryCode()));
+                        if (allowedLoc == null || allowedLoc.isEmpty()) {
+                            inventoryList = Collections.emptyList();
+                        } else {
+                            inventoryList = inventoryList.stream()
+                                .filter(inv -> allowedLoc.contains(inv.getLocationId()))
+                                .collect(Collectors.toList());
+                        }
+                    }
                     // 库存信息
                     baseDto.setInventoryList(inventoryList);
                     // 设置默认产品批号
@@ -174,18 +198,15 @@ public class DoctorStationAdviceAppServiceImpl implements IDoctorStationAdviceAp
                             baseDto.setDefaultLotNumber(hasInventoryList.get(0).getLotNumber());
                         }
                     }
-                    if (!inventoryList.isEmpty() && !medLocationConfig.isEmpty()) {
-                        // 第一步：在medLocationConfig中匹配categoryCode
-                        AdviceInventoryDto result1 = medLocationConfig.stream()
-                            .filter(dto -> baseDto.getCategoryCode().equals(dto.getCategoryCode())).findFirst()
-                            .orElse(null);
-                        if (result1 != null) {
-                            // 第二步：在inventoryList中匹配locationId
-                            AdviceInventoryDto result2 = inventoryList.stream()
-                                .filter(dto -> result1.getLocationId().equals(dto.getLocationId())).findFirst()
-                                .orElse(null);
-                            if (result2 != null && result2.getLotNumber() != null) {
-                                baseDto.setDefaultLotNumber(result2.getLotNumber());
+                    if (!inventoryList.isEmpty() && !allowedLocByCategory.isEmpty()) {
+                        Set<Long> allowedLoc =
+                            allowedLocByCategory.get(String.valueOf(baseDto.getCategoryCode()));
+                        if (allowedLoc != null && !allowedLoc.isEmpty()) {
+                            AdviceInventoryDto hit = inventoryList.stream()
+                                .filter(inv -> allowedLoc.contains(inv.getLocationId()))
+                                .findFirst().orElse(null);
+                            if (hit != null && hit.getLotNumber() != null) {
+                                baseDto.setDefaultLotNumber(hit.getLotNumber());
                             }
                         }
                     }